|
KMID : 0359319940340010063
|
|
Korean Journal of Veterinary Research
1994 Volume.34 No. 1 p.63 ~ p.67
|
|
|
Effect of berberine on intestinal contractility
|
|
|
|
|
Abstract
|
|
|
Berberine(10^(-7)-10^(-5)M) increased the contractility dose-dependently in isolated rabbit ileal and jejunal segments. Atropine and hemicholinium abolished this response but not mecamylamine. Berberine(10^(-8)-10^(-5)M) enhanced the transmurally-stimulated(80 V, 0.5 ms, 0.05 ㎐) twitch response in the isolated guinea-pig ileal segments. Atropine and hemicholinium also abolished this response but not mecamylamine. Effect of KCI, carbachol and histamine were not affected by pretreatment with berberine(10^(-5)M).
The results of our study suggest that berberine increases the intestinal contractility by increasing a small amount of acerylcholine release from the postganglionic parasympathetic nerve terminal but not by a direct activation of muscarinic receptors.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|